serum corticosterone Search Results


serum corticosterone (cort) assay  (Arbor Assays)
90
Arbor Assays serum corticosterone (cort) assay
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone (Cort) Assay, supplied by Arbor Assays, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc11687612-105-1-26?v=Arbor+Assays
Average 90 stars, based on 1 article reviews
serum corticosterone (cort) assay - by Bioz Stars, 2026-08
90/100 stars
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serum corticosterone  (Enzo Biochem)
90
Enzo Biochem serum corticosterone
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc09280910-247-0-12?v=Enzo+Biochem
Average 90 stars, based on 1 article reviews
serum corticosterone - by Bioz Stars, 2026-08
90/100 stars
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rabbit anti-corticosterone serum  (ICN Biomedicals)
90
ICN Biomedicals rabbit anti-corticosterone serum
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Rabbit Anti Corticosterone Serum, supplied by ICN Biomedicals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pm24631553-113-0-3?v=ICN+Biomedicals
Average 90 stars, based on 1 article reviews
rabbit anti-corticosterone serum - by Bioz Stars, 2026-08
90/100 stars
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serum corticosterone  (Cayman Chemical)
90
Cayman Chemical serum corticosterone
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/10__1186_slash_1476___511x___10___11-71-13-21?v=Cayman+Chemical
Average 90 stars, based on 1 article reviews
serum corticosterone - by Bioz Stars, 2026-08
90/100 stars
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anti-corticosterone fka420-e  (Cosmo Bio USA)
90
Cosmo Bio USA anti-corticosterone fka420-e
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Anti Corticosterone Fka420 E, supplied by Cosmo Bio USA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc03914875-105-18-22?v=Cosmo+Bio+USA
Average 90 stars, based on 1 article reviews
anti-corticosterone fka420-e - by Bioz Stars, 2026-08
90/100 stars
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rabbit anti-corticosterone serum (diluted 1:17,500  (ICN Pharmaceuticals)
90
ICN Pharmaceuticals rabbit anti-corticosterone serum (diluted 1:17,500
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Rabbit Anti Corticosterone Serum (Diluted 1:17,500, supplied by ICN Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc01950324-109-44-50?v=ICN+Pharmaceuticals
Average 90 stars, based on 1 article reviews
rabbit anti-corticosterone serum (diluted 1:17,500 - by Bioz Stars, 2026-08
90/100 stars
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corticosterone stress hormone assay serum  (IBL America)
90
IBL America corticosterone stress hormone assay serum
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Corticosterone Stress Hormone Assay Serum, supplied by IBL America, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc06346300-127-0-22?v=IBL+America
Average 90 stars, based on 1 article reviews
corticosterone stress hormone assay serum - by Bioz Stars, 2026-08
90/100 stars
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serum corticosterone kit 07120102  (ICN Pharmaceuticals)
90
ICN Pharmaceuticals serum corticosterone kit 07120102
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone Kit 07120102, supplied by ICN Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pm15166122-62-8-12?v=ICN+Pharmaceuticals
Average 90 stars, based on 1 article reviews
serum corticosterone kit 07120102 - by Bioz Stars, 2026-08
90/100 stars
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corticosterone-3- (o-carboxymethyl)oxime-bovine serum albumin conjugate  (BioClinical Partners)
90
BioClinical Partners corticosterone-3- (o-carboxymethyl)oxime-bovine serum albumin conjugate
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Corticosterone 3 (O Carboxymethyl)oxime Bovine Serum Albumin Conjugate, supplied by BioClinical Partners, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pmc01592225-122-12-17?v=BioClinical+Partners
Average 90 stars, based on 1 article reviews
corticosterone-3- (o-carboxymethyl)oxime-bovine serum albumin conjugate - by Bioz Stars, 2026-08
90/100 stars
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serum corticosterone  (DSL Inc)
90
DSL Inc serum corticosterone
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone, supplied by DSL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pm23290636-74-0-7?v=DSL+Inc
Average 90 stars, based on 1 article reviews
serum corticosterone - by Bioz Stars, 2026-08
90/100 stars
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corticosterone serum concentrations were determined by elisa assay  (Enzo Biochem)
90
Enzo Biochem corticosterone serum concentrations were determined by elisa assay
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Corticosterone Serum Concentrations Were Determined By Elisa Assay, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pm29759136-71-6-15?v=Enzo+Biochem
Average 90 stars, based on 1 article reviews
corticosterone serum concentrations were determined by elisa assay - by Bioz Stars, 2026-08
90/100 stars
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serum corticosterone content kits  (Becton Dickinson)
90
Becton Dickinson serum corticosterone content kits
Box-and-whisker plots for E 2 and <t>CORT</t> concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, <t>corticosterone;</t> D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.
Serum Corticosterone Content Kits, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/serum+corticosterone/pm21864582-83-0-7?v=Becton+Dickinson
Average 90 stars, based on 1 article reviews
serum corticosterone content kits - by Bioz Stars, 2026-08
90/100 stars
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Image Search Results


Box-and-whisker plots for E 2 and CORT concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, corticosterone; D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.

Journal: Environmental Health Perspectives

Article Title: Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin

doi: 10.1289/EHP15621

Figure Lengend Snippet: Box-and-whisker plots for E 2 and CORT concentration data from each generation of behaviorally characterized female rats (F1, F3, F4, and F6). The horizontal lines indicate median scores, boxes represent upper and lower score quartiles and comprise 50% of the data, vertical whiskers represent the spread of data points outside of the upper and lower quartiles, and points represent potential outlier datapoints that fall 1.5 times above or below the main distribution. F1 rats exposed to A1221 had a significantly higher serum E 2 concentration in comparison with DMSO controls. (A) ** Tukey’s HSD: p = 0.002 ; and F3 paternal VIN rats had significantly lower serum E 2 concentration in comparison with DMSO controls. (C) ** Tukey’s HSD: p = 0.007 . (E,G) E 2 concentration was not different among any groups in the F4 and F6 generations, and (B,D,F,H) CORT was not different among any groups across all generations. Summary data can be found in Table S5. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, corticosterone; D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; E 2 , estradiol; HSD, honestly significant difference; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.

Article Snippet: Circulating serum corticosterone (CORT) was assayed from the same subset of rats and was quantified by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s protocol (K014-H5; Arbor Assays) using a GlowMax Multi + detection system (Promega).

Techniques: Whisker Assay, Concentration Assay, Comparison

Scatterplots with linear regression lines displaying the correlation between PC1 scores (behavior ratios) and standardized serum CORT concentrations ( z -scores). Each point represents an individual, colored according to their EDC treatment group. Regression lines indicate trends within each treatment group (shown on separate panels for clarity), highlighting variations in the relationship between behavioral components captured by PC1 and physiological responses measured by CORT. (A) Serum CORT explained 12.8% of the variation (adjusted R 2 ) in the PC1 scores of the F3 paternal line rats; 21.8% of the variation in the PC1 scores of the F4 paternal line rats with a significant and positive interaction between CORT and PC1 among the V/A-exposed rats. (B) ***Tukey’s HSD: p < 0.001 ; and 5.5% of the variation in the PC1 scores of the F6 maternal line rats with a significant and positive interaction between CORT and PC1 among the A1221/A1221-exposed rats. (C) **Tukey’s HSD: p = 0.009 . Summary data can be found in Table S6. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, corticosterone; D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; EDC, endocrine-disrupting chemical; HSD, honestly significant difference; PC1, Principal Component 1; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.

Journal: Environmental Health Perspectives

Article Title: Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin

doi: 10.1289/EHP15621

Figure Lengend Snippet: Scatterplots with linear regression lines displaying the correlation between PC1 scores (behavior ratios) and standardized serum CORT concentrations ( z -scores). Each point represents an individual, colored according to their EDC treatment group. Regression lines indicate trends within each treatment group (shown on separate panels for clarity), highlighting variations in the relationship between behavioral components captured by PC1 and physiological responses measured by CORT. (A) Serum CORT explained 12.8% of the variation (adjusted R 2 ) in the PC1 scores of the F3 paternal line rats; 21.8% of the variation in the PC1 scores of the F4 paternal line rats with a significant and positive interaction between CORT and PC1 among the V/A-exposed rats. (B) ***Tukey’s HSD: p < 0.001 ; and 5.5% of the variation in the PC1 scores of the F6 maternal line rats with a significant and positive interaction between CORT and PC1 among the A1221/A1221-exposed rats. (C) **Tukey’s HSD: p = 0.009 . Summary data can be found in Table S6. Note: A1221, Aroclor 1221; A/A, first exposure A1221/second exposure A1221; A/V, first exposure A1221/second exposure VIN; CORT, corticosterone; D/D, first exposure DMSO/second exposure DMSO; DMSO, dimethyl sulfoxide; EDC, endocrine-disrupting chemical; HSD, honestly significant difference; PC1, Principal Component 1; V/A, first exposure VIN/second exposure A1221; V/V, first exposure VIN/second exposure VIN; VIN, vinclozolin.

Article Snippet: Circulating serum corticosterone (CORT) was assayed from the same subset of rats and was quantified by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s protocol (K014-H5; Arbor Assays) using a GlowMax Multi + detection system (Promega).

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